Wednesday, July 8, 2009

Boron cancer threrapy part 2

I wanted to talk more about the Boron therapy for cancer that Dr Soria talked about in his class. The ideal therapy is the one in which only the cancerous cells are destroyed without damaging healthy tissue or affecting the function of important systems specially when treating brain tumors because the cells of the brain are the most sensitive and the ones with the most important function. BNCT is a technique that uses radiation to destroy the cells but the way it works is different and is much more selective because it destroys only the cells close to the target cell.
This is not the typical radiation technique since the beam does not destroy all of the tumor cells but the target cell is one which contains an isotope of boron. The key in this process is that the boron attaches to the cancer cell by attaching it to compunds that have special affinity for tumor cells.

The basic principle for the neutron capture therapy. A higher concentration of Boron exists in the tumor cells than in the nomrmal ones. Nuclides have different affinity for the thermal neutrons absoption. Of the nucleides that have this affinity B-10 is the most attractive because it is not radioactive and is very avaliable. Even if the affinity of most of the tissues is the highest for boron there are considerably amounts of nitrogen and hydrogen and its content inside the cell are significant. To avoid the presence of these undesirable isotopes the high amounts of Boron 10 are attached to the cell until the point that is saturates the cell.

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